Mental Health

How Much Does Zoloft Cost Without Insurance in 2023?

Ashley Brooks
Ashley Brooks8 Jul 2023

Without insurance, Zoloft can cost over $500 depending on where you obtain the prescription. Opting for the generic version or subscribing to a prescription service can help save you hundreds on your Zoloft prescription. Zoloft is an antidepressant medication that helps treat a range of psychiatric conditions. 

Mira provides up to 80 percent discounted rates on over 1,000 prescriptions - including Zoloft. With Mira, you also get affordable access to urgent care visits and preventative labs. Coming soon, virtual behavioral health and primary care will be covered as well. Join today! 

The Cost of Zoloft

The cost of Zoloft can be well over $500 when paying out of pocket. Costs can vary depending on the number of pills in a single prescription, whether you opt for brand name versus generic, and the pharmacy in which you get your prescription. If you don’t have insurance, you may want to consider a prescription subscription service or discount membership such as MiraRx, which can reduce the cost by hundreds of dollars.

Below is a comparison of the cost of brand name Zoloft compared to the generic Sertraline HCl at different retail pharmacies. The cost is based on a prescription of 30 count, 50mg tablets. 

The Cost of Zoloft vs. Sertraline HCI at Different Pharmacies

PharmacyZoloft Sertraline HCl 
CVS Pharmacy$432.739$34.52

Source: Single Care

Factors that Influence the Cost of Zoloft

Factors such as the pharmacy location, brand name or generic version, insurance status, and dosage can determine the cost of your Zoloft prescription. 

Brand Name vs. Generic

Brand name prescription drugs are sold by drug companies with a specific name and are patented. They are oftentimes sold at a price that is significantly less than the brand name version.

The first table shows that the brand name Zoloft is significantly more expensive than its generic version. At CVS Pharmacy, a prescription of 30 count, 50mg tablets of Zoloft cost about $432 while the generic version Sertraline HCI costs $34 for the same amount. If you want to save money on your prescription, ask your psychologist to prescribe the generic version instead.


As you can see from the table above, the cost of Zoloft varies by retailer. The pharmacy you get your prescription filled at may be different than another. This cost can vary significantly, so if you are concerned about the price you’re paying, you may want to shop around and ask different pharmacies how much your prescription will cost. 

To check the price of Zoloft or Sertraline HCl at various pharmacies near you, you can use the MiraRx tool to see how much you can save by comparing those that offer the prescription in your area. 

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Insurance Status

Your insurance status will also determine how much you will pay for your Zoloft prescription. It is likely that Zoloft or the generic version of Sertraline is on your insurance plan’s list of covered prescriptions. In this case, you could pay as little as $0. Check your Summary of Benefits and Coverage to find out. 

Otherwise, if you are paying out-of-pocket for brand name Zoloft, you may find yourself paying hundreds of dollars out-of-pocket.


The greater number of pills in your prescription - say 30 pills compared to 100 pills per prescription refill will also indicate the cost. More prescriptions in one pill bottle will increase the cost, but if you are refiling monthly, this may save you money over time. The dosage does not impact the cost by much.

Below is a table comparing the price of Zoloft out-of-pocket without insurance or discounts based on the form, dosage, and quantity.

Cost of Zoloft Based on Quantity & Dosage

Oral Concentrate20mg60mL$273.70
Oral Tablet25mg30 tablets$393.84
Oral Tablet50mg30 tablets$139.01 – $393.84
Oral Tablet100mg30 tablets$393.84


Zoloft Frequently Asked Questions (FAQs)

Consider the following questions regarding Zoloft when discussing with your doctor whether this medication is right for you and how to save on your prescription.

What does Zoloft treat?

Zoloft and the generic Sertraline are antidepressant medications approved for the treatment of major depressive disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, panic disorder, and social anxiety disorder. This medication can also be used to treat obsessive-compulsive disorder for children and adults. 

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What are the side effects of Zoloft?

According to the National Alliance on Mental Illness, common side effects include headache, nausea, diarrhea, dry mouth, increased sweating, feelings of being nervous, restless, fatigued, or insomnia. More rare, but serious side effects can also occur such as the increased risk of bleeding events, especially when combined with aspirin, ibuprofen, naproxen, or other anticoagulants. Antidepressants may also increase the risk of suicide ideation. 

How do I save money on my Zoloft prescription?

As you can see from the table shown above, the cost of Zoloft is significantly lower when opting for the generic version, Sertraline. Both Zoloft and Sertraline HCl work in the same way with the same dosage, safety, strength, route of administration, quality, and performance. Another way to save is by subscribing to a low-cost prescription service such as MiraRX. 

Who can prescribe Zoloft?

Family medicine doctors and other licensed physicians can prescribe antidepressants such as Zoloft. Family or primary care physicians typically screen for depression and other psychiatric conditions and may recommend Zoloft as a treatment option, but are likely to refer you to a psychiatrist or other psychiatric counselor. 

However, a psychologist cannot prescribe medication, while they have advanced degrees often in clinical psychology, a licensed psychiatrist is a medical doctor that is able to prescribe medications such as antidepressants. 

What are common symptoms of the psychiatric disorders Zoloft treats?

Below are some descriptions of the psychiatric disorders that Zoloft typically helps treat according to:

  • Depression: Feelings of sadness, emptiness, or tearfulness, as well as the feeling of being worthless, guilty, hopeless, or helpless. One with depression may also experience a loss of interest or pleasure in usual activities while sleeping and eating more or less than usual. Such individuals may also have low energy, difficulty concentration, or suicide ideations.
  • Post-Traumatic Stress Disorder (PTSD): when a person experiences a traumatic event and later feels on edge or avoids situations that remind them of the event and may experience flashbacks or nightmares.
  • Premenstrual Dysphoric Disorder (PMDD): is often diagnosed when a woman experiences depression, tension, or irritability during the days prior to menstruation and is more severe than symptoms of premenstrual syndrome (PMS).
  • Panic Disorder: When a person experiences unexpected and repeated episodes of intense fear, as well as fear of future episodes. . Physical symptoms may be experienced as chest pain, shortness of breath, heart palpitations, dizziness, nausea.
  • Obsessive-Compulsive Disorder: When a person experiences symptoms of obsessions and compulsions simultaneously. Obsessions indicate unwanted, recurrent, and disturbing thoughts, while compulsions indicate repetitive and ritualized behaviors they must perform to reduce anxiety associated with the obsessions.

Bottom Line 

Zoloft can cost between $300 and $500, but when opting for the generic version, Sertraline HCl, you can save hundreds of dollars. Your pharmacy, the prescription type (generic or brand name), insurance status, and your subscription to prescription discount services will determine the cost you pay for your antidepressants and other medications. 

If you are concerned about paying for your antidepressant medication out-of-pocket, Mira can help you save. With a Mira membership, you get access to up to 80 percent discounted rates on over 1,000 medications, affordable urgent care visits, and low-cost lab testing. Sign up today.

Ashley Brooks

Ashley Brooks works in Healthcare Consulting and graduates with her MPH in September of 2022 from George Washington University, but graduated with her B.S. in Health Science from James Madison University in 2019. Ashley has been with Mira since June of 2021 and shares the passion for creating affordable healthcare coverage for all!