How Much Does Omeprazole Cost Without Insurance in 2024?

Omeprazole is a common prescription drug and over-the-counter (OTC) medication commonly used to treat heartburn. Omeprazole is the generic name but can be found under the brand name Prilosec or Prilosec OTC. Costs vary, depending on whether it is prescribed or purchased OTC and depending on the form and quantity. Without insurance, omeprazole costs between $8 and $110 without insurance or any discounts. 

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The Cost of Omeprazole without Insurance

Not all health insurance plans cover the cost of prescription drugs, and many prescriptions can break the bank without insurance or without a plan that offers Rx coverage. If you have Medicare, it may also depend on whether you have a Part D benefit. Thankfully, omeprazole, a common prescription drug used to treat heartburn and other conditions, is also available over-the-counter (OTC) at local pharmacies for about $20.  

Below is a breakdown of the average cost of the prescription version without insurance compared to the over-the-counter version of omeprazole offered at the same facility. Rates are based on a quantity of 42 20mg tablets of the 24-hour generic omeprazole.

The Cost of Omeprazole at Different Pharmacies

The Cost of Omeprazole at Different Pharmacies Based on Drug Count

Without insurance, you can expect to pay more for the prescription version, especially from certain locations. Speak with your doctor on whether the OTC version could be used as a supplemental treatment instead of the prescription. Depending on your location, you may have to pay upwards of $100 for your omeprazole prescription or more. Thankfully, many discount opportunities exist, such as MiraRx.