How Much Do Compounded Semaglutide and Tirzepatide Cost?
IMPORTANT: Understand The Difference Between Dosage vs. Concentration
When dealing with compounded medications, it's important to grasp the difference between dosage and concentration and the quantity of liquid in a vial, as this affects how much you pay. Based on your dose, a $100 vial of medication could last you a month or two and that makes a huge difference in costs.
Dosage vs. Concentration: Dosage refers to the amount of medication you take, usually measured in milligrams (mg). Concentration tells you how much medication is in each milliliter (mL) of liquid. For example, if you have a 1ml vial and the label says 10 mg/mL, that means there are 10 mg of medication within that entire vial.
Cost Understanding: The price of a vial can seem confusing. A vial with more liquid or a higher concentration of medication might cost more, but it could also mean you're getting more doses out of it, which might actually save money in the long run.
For instance, if you need 10 mg of your medication monthly. Which vial below is the cheaper option?
- Vial A: 1ml of 5 mg/mL, costs $100, there is a total of 10mg of the medication
- Vial B: 0.5ml of 20 mg/ml, costs $100, there is a total of 10mg of the medication
| Description | Vial A | Vial B |
|---|---|---|
| Concentration (mg/mL) | 5 mg/mL | 20 mg/mL |
| Volume (mL) | 1 mL | 0.5 mL |
| Total Medication (mg) | Total 5 mg | Total 10 mg |
| Cost per Vial ($) | $100/vial | $100/vial |
| How Many Vials You Need (assume 10mg/mo dose) | 2 vials/mo | 1 vial/mo |
| Your monthly cost | $200/mo | $100/mo |
In this example, we demonstrate that though Vial A seems like a better buy because it has more liquid, it turns out to be twice as expensive as Vial B. This is because it is not as concentrated. While evaluating the cost of compounded medications, it is important to remember to do some maths and figure out the monthly cost for your dosage.
General Dosage for Semaglutide and Tirzepatide
Semaglutide General Dosage For Weight Management:
- Start: 0.25 mg once weekly for 4 weeks.
- Gradual Increase: Increase the dose every 4 weeks through incremental steps (0.5 mg, 1 mg, 1.7 mg) up to 2.4 mg once weekly.
| Month | Total Dose |
|---|---|
| Month 1 | 1 mg (0.25 mg x 4 weeks) |
| Month 2 | 2 mg (0.5 mg x 4 weeks) |
| Month 3 | 3 mg (or 4 mg depending on adjustment at Week 9) |
Tirzepatide General Dosage For Weight Management:
Tirzepatide is another medication used for the treatment of type 2 diabetes, with its dosing regimen being:
- Start: 2.5 mg once weekly for 4 weeks.
- Increase to 5 mg: After 4 weeks, increase the dose to 5 mg once weekly.
- Further Increases: Depending on the efficacy and tolerability, the dose can be increased to 10 mg once weekly after at least 4 weeks on the 5 mg dose, and potentially to 15 mg once weekly after at least another 4 weeks.
| Month | Total Dose |
|---|---|
| Month 1 | 10 mg (2.5 mg x 4 weeks) |
| Month 2 | 20 mg (5 mg x 4 weeks) |
| Month 3 | 40 mg (depending on adjustment at Week 9) |
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Khang T. Vuong received his Master of Healthcare Administration from the Milken Institute School of Public Health at the George Washington University. He was named Forbes Healthcare 2021 30 under 30. Vuong spoke at Stanford Medicine X, HIMSS conference, and served as a Fellow at the Bon Secours Health System.